Simple 1,2-aminoalcohols as strain-specific antimalarial agents

Authors
Howarth, J Lloyd, DG
Citation
J. Howarth et Dg. Lloyd, Simple 1,2-aminoalcohols as strain-specific antimalarial agents, J ANTIMICRO, 46(4), 2000, pp. 625-627
Citations number
10
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
46
Issue
4
Year of publication
2000
Pages
625 - 627
Database
ISI
SICI code
Abstract
We report here the in vitro activity of a selection of 1,2-aminoalcohol-con taining compounds against cloned strains of human Plasmodium falciparum. Th ese compounds exhibit moderate antimalarial activity but a high degree of s train specificity, preferentially inhibiting a chloroquine-resistant strain of the organism.