Kinetics of respiratory system elastance after airway challenge in dogs

We compared the time courses of lung mechanical changes with intravenous (i v) injection vs, aerosol administration of histamine, methacholine, and ACh in dogs. We interpret these results in terms of a spring-and-dashpot model of airway smooth muscle receiving activation via a tissue compartment when agonist is delivered by the iv route and through an additional airway wall compartment when it is delivered by the aerosol route. The model accuratel y accounts for the principal features of the respiratory system elastance r esponse curves. It also accounts for the differences between iv and aerosol responses, supporting the notion that agonist delivered by aerosol has to traverse a longer pathway to the airway smooth muscle than does agonist del ivered iv. The time constants representing diffusive exchange of agonist be tween compartments were not significantly different for the three agonists, suggesting that the three agonists shared a common principal means of clea rance, which was presumably blood flow.