A transgenic strategy for analysis of the function of the endothelin-B-receptor

Authors
Bagnall, A Webb, D Kotelevtsev, Y
Citation
A. Bagnall et al., A transgenic strategy for analysis of the function of the endothelin-B-receptor, J CARDIO PH, 36, 2000, pp. S90-S92
Citations number
19
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
ISSN journal
01602446 → ACNP
Volume
36
Year of publication
2000
Supplement
1
Pages
S90 - S92
Database
ISI
SICI code
0160-2446(2000)36:<S90:ATSFAO>2.0.ZU;2-9
Abstract
Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (E T) receptor knockouts has been complicated by the development of lethal phe notypes. In this paper, we present our strategy for examining endothclin-B- (ETB) receptor function in the context of other strategies for rescuing the lethal phenotype of ETB knockout mice.