Ancistrolikokines A-C: New 5,8 '-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko

Authors
Bringmann, G Gunther, C Saeb, W Mies, J Wickramasinghe, A Mudogo, V Brun, R
Citation
G. Bringmann et al., Ancistrolikokines A-C: New 5,8 '-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko, J NAT PROD, 63(10), 2000, pp. 1333-1337
Citations number
16
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
10
Year of publication
2000
Pages
1333 - 1337
Database
ISI
SICI code
0163-3864(200010)63:10<1333:AAN5'N>2.0.ZU;2-1
Abstract
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as wel l as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancist rocladus species. Compounds 1-4 showed good to moderate antimalarial activi ties when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.