A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells

Authors
Nagle, DG Zhou, YD Park, PU Paul, VJ Rajbhandari, I Duncan, CJG Pasco, DS
Citation
Dg. Nagle et al., A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells, J NAT PROD, 63(10), 2000, pp. 1431-1433
Citations number
14
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
10
Year of publication
2000
Pages
1431 - 1433
Database
ISI
SICI code
0163-3864(200010)63:10<1431:ANIFTM>2.0.ZU;2-N
Abstract
A new indanone (1) has been isolated from the filamentous marine cyanobacte rium Lyngbya majuscula, and its structure determined spectroscopically. Vas cular endothelial growth factor (VEGF) is an important regulator of tumor a ngiogenesis. Compound 1 inhibits hypoxia-induced activation of the VEGF gen e promoter in Hep3B human liver tumor cells, in vitro.