Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase (TM) grafted solid-supports

A replacement of the acetic acid moiety by valeric acid within the 4-hydrox ymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labi le resin linkage agents for use in solid phase peptide synthesis. Int. J. P eptide Protein Res. 1982; 20: 451-454) significantly improved its performan ce in terms of loading capacity, yield and purity of the final products, Th e results indicated the spacer-linker combination and type of solid support s are important factors for solid-phase synthesis. Copyright (C) 2000 Europ ean Peptide Society and John Wiley & Sons, Ltd.