Blood cadmium (B-Cd) and urinary cadmium (U-Cd) were assessed among non-smo
kers, cigarette smokers, sheesha smokers, and both cigarette and sheesha sm
okers. Urinary cotinine (U-cotinine), which is a metabolite of nicotine wit
h a biological half-life of >10 h was used as a marker of exposure to tobac
co smoke. Results indicate that smoking sheesha is another source of tobacc
o exposure. B-Cd, U-Cd, and U-cotinine were significantly higher among ciga
rette and both cigarette and sheesha smokers. U-cotinine was associated onl
y with B-Cd concentrations. Exposure to Cd from smoking cigarette or/and sh
eesha could effect some of the renal dysfunction indices.