A NOTE: Ortho-Phthalaldehyde: proposed mechanism of action of a new antimicrobial agent

Authors
Simons, C Walsh, SE Maillard, JY Russell, AD
Citation
C. Simons et al., A NOTE: Ortho-Phthalaldehyde: proposed mechanism of action of a new antimicrobial agent, LETT APPL M, 31(4), 2000, pp. 299-302
Citations number
17
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
LETTERS IN APPLIED MICROBIOLOGY
ISSN journal
02668254 → ACNP
Volume
31
Issue
4
Year of publication
2000
Pages
299 - 302
Database
ISI
SICI code
0266-8254(200010)31:4<299:ANOPMO>2.0.ZU;2-X
Abstract
Ortho-phthalaldehyde (OPA) is a new aromatic dialdehyde antimicrobial agent , the mechanism of action of which has been little studied. The aims of thi s paper are to examine what is currently known about its mechanism of actio n, to compare the action with that of a widely investigated aliphatic diald ehyde, glutaraldehyde (GTA), and to put forward a hypothesis that would, in the light of current knowledge, explain how OPA inactivates micro-organism s, including GTA-resistant Mycobacterium chelonae.