Ca. Dujovne et al., Randomized comparison of the efficacy and safety of cerivastatin and pravastatin in 1030 hypercholesterolemic patients, MAYO CLIN P, 75(11), 2000, pp. 1124-1132
Citations number
26
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Objective: To determine the relative efficacy and safety of cerivastatin an
d pravastatin in patients with type II hypercholesterolemia.
Patients and Methods: In this prospective, double-blind, parallel-group stu
dy, hypercholesterolemic patients were randomized to treatment with cerivas
tatin, 0.3 mg (n=250) or 0.4 mg (n=258), or pravastatin, 20 mg (n=266) or 4
0 mg (n=256), for 8 weeks.
Results: Cerivastatin, 0.3 mg, was significantly more effective than pravas
tatin, 20 mg, in reducing low-density lipoprotein (LDL) cholesterol from ba
seline (-29.6% vs -26.8%; P=.008), Cerivastatin,0.4 mg, was significantly m
ore effective than pravastatin, 40 mg, in reducing LDL cholesterol (34.2% v
s -30.3%; P<.001), A larger proportion of cerivastatin-treated patients had
greater than 40% reductions in LDL cholesterol than those receiving pravas
tatin (11.1% vs 6.0%). The percentage of patients who achieved the National
Cholesterol Education Program (NCEP) target was 71.3% with cerivastatin, 0
.3 mg, compared with 67.5% with pravastatin, 20 mg, and 74.0% with cerivast
atin, 0.4 mg, compared with 71.1% with pravastatin, 40 mg (no significant d
ifference), Cerivastatin, 0.3 mg, reduced total cholesterol to a greater ex
tent than did pravastatin, 20 mg (P<.03). Both agents reduced triglycerides
and increased high-density lipoprotein cholesterol to a similar degree (no
significant differences). Cerivastatin and pravastatin were well tolerated
.
Conclusions: Cerivastatin, 0.3 mg and 0.4 mg, showed greater efficacy than
pravastatin, 20 mi: and 40 mg, respectively, in lowering LDL cholesterol, C
erivastatin is safe and effective for patients with hypercholesterolemia wh
o require aggressive LDL cholesterol lowering to achieve NCEP-recommended t
argets.