Virtual colonoscopy compared with conventional colonoscopy: a developing technology

Aim: To determine the accuracy of computed tomography colography (virtual c olonoscopy) in detecting colorectal polyps and colorectal cancer. Design: Blinded comparison of virtual colonoscopy (initially supine-only sc ans and later supine plus prone scans) with the criterion standard of conve ntional colonoscopy. Subjects and setting: 100 patients aged 55 years or over referred to a publ ic teaching hospital for colonoscopy, July 1997 to January 2000, because of colonic symptoms or a family history of bower cancer. Main outcome measures: Presence and size of polyps and other lesions; certa inty of polyp identification on virtual colonoscopy (on 100-point visual an alogue scale); sensitivity and predictive values of virtual colonoscopy. Results: Conventional colonoscopy identified 121 polyps in 47 patients; 28 of these polyps, in 19 patients, were identified by virtual colonoscopy. Se nsitivity of virtual colonoscopy for detecting polyps (using supine plus pr one scans) was 73% for polyps with diameter greater than or equal to 10 mm (95% CI, 39%-94%) and 19% for smaller polyps (95% CI, 10%-31%) (P < 0.001); corresponding figures for supine-only scans were 57% (95% CI, 18%-90%) and 11% (95% CI, 4%-24%), respectively. Ten polyps identified at virtual colon oscopy were considered false-positive findings (8%). The value of finding a polyp on virtual colonoscopy (with thresholds of 5 mm for diameter and 30 points for certainty score) was assessed as a predictor of finding a polyp (diameter > 5 mm) on conventional colonoscopy. Positive and negative predic tive values were 88% and 89%, respectively, for supine plus prone scans. Conclusion: Although virtual colonoscopy shows potential as a diagnostic to ol for colorectal neoplasia, it is currently not sufficiently sensitive for widespread use.