Newton's law gets modified in the presence of a cosmological constant by a
small repulsive term (antigravity) that is proportional to the distance. As
suming a value of the cosmological constant consistent with the recent SnIa
data (Lambda similar or equal to 10(-52) m(-2)), we investigate the signif
icance of this term on various astrophysical scales. We find that on galact
ic scales or smaller (less than a few tens of kpc), the dynamical effects o
f the vacuum energy are negligible by several orders of magnitude. On scale
s of 1 Mpc or larger however we find that the vacuum energy can significant
ly affect the dynamics. For example we show that the velocity data in the l
ocal group of galaxies correspond to galactic masses increased by 35% in th
e presence of vacuum energy. The effect is even more important on larger lo
w density systems like clusters of galaxies or superclusters.