NF-kappa B as a therapeutic target in chronic inflammation: recent advances

The family of nuclear factor kappaB (NF-kappaB) transcription factors is a topic of intense interest in the biomedical community stemming from the rol e NF-kappaB plays in almost every aspect of cell regulation: stress respons es, immune cell activation, apoptosis, proliferation, differentiation and o ncogenic transformation. The objective of this article is to provide an ove rview of recent developments in the field with an emphasis on the role of N F-kappaB in chronic inflammation, and to discuss the feasibility of therape utic approaches based on the specific suppression of the NF-kappaB pathway.