In this paper we use a control strategy that enhances a fuzzy controller wi
th self-learning capability for achieving the control of a binary methanol-
propanol distillation column. An adaptive-Network-based Fuzzy Interference
System (ANFIS) architecture extended to cope with multivariate systems has
been used. This allows the tuning of parameters both of the membership func
tions and the consequents in a Sugeno-type interference system. To satisfy
the control objectives the backpropagation gradient descent through the pla
nt method is applied, hence identification of the plant dynamics is also ne
eded. The performance of the resulting neuro-fuzzy controller under differe
nt reference settings for the concentration of methanol demonstrates the st
abilisation of the concentration profiles in the column leading to an effec
tive methanol composition control.