Entering through the doors of perception: characterization of a highly selective substance P receptor-targeted toxin

Perception of external stimuli is often mediated through the activity of a G protein-coupled receptor in response to its ligand. Receptor-mediated int ernalization allows the insertion of toxins that cause the elimination of r eceptor-expressing neurons. Using this technique new information on systems biology can be discovered and with this, new therapeutics developed. (C) 2 000 Harcourt Publishers Ltd.