The synthesis of novel 6,5-and 6,6-membered fused heterocyclic compounds derived from thymine

Authors
Jokic, M Raza, Z Katalenic, D
Citation
M. Jokic et al., The synthesis of novel 6,5-and 6,6-membered fused heterocyclic compounds derived from thymine, NUCLEOS NUC, 19(9), 2000, pp. 1381-1396
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
9
Year of publication
2000
Pages
1381 - 1396
Database
ISI
SICI code
1525-7770(2000)19:9<1381:TSON66>2.0.ZU;2-K
Abstract
Novel pyrimido[1,2-a]pyrimidinones 14, 15 and 16 and imidazo[1,2-a] pyrimid inones 19 and 20, designed as conformationally constrained analogues of 1-( 3-amino-2-hydroxypropyl)thymine and 1-(2-amino-3-hydroxypropyl)thymine, res pective ly, were synthesized by the ring-opening/ ring-closure rearrangemen t of the corresponding byciclic oxygen-containing amino compounds 12 and 17 .