Synthesis and antiviral activity of C-5 substituted beta-D- and beta-L-D4Tanalogues

Authors
Delbederi, Z Fossey, C Fontaine, G Benzaria, S Gavriliu, D Ciurea, A Lelong, B Laduree, D Aubertin, AM Kirn, A
Citation
Z. Delbederi et al., Synthesis and antiviral activity of C-5 substituted beta-D- and beta-L-D4Tanalogues, NUCLEOS NUC, 19(9), 2000, pp. 1441-1461
Citations number
34
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
9
Year of publication
2000
Pages
1441 - 1461
Database
ISI
SICI code
1525-7770(2000)19:9<1441:SAAAOC>2.0.ZU;2-T
Abstract
A series of beta -D-2',3'-didehydro-2',3'-dideoxy-nucleosides bearing a tet her attached at the C-5 position and their beta -L-counterparts was synthes ized. Their inhibitory activities against human immunodeficiency virus (HIV ) were investigated and compared to establish relationship(s) between compo und structure and their antiviral activity. No significant activity was obs erved for beta -D- and beta -L-modified nucleosides respectively 7a-c and 1 4a-c, but 7d and 14d exhibited a weak activity against HIV-1.