Clear cell adenocarcinoma of the cervix associated with a rare genitourinary malformation

Background: Cervical adenocarcinoma and genitourinary malformations are rel atively common disorders, yet their coexistence is rare. Case: A 49-year-old woman developed clear cell adenocarcinoma in the atreti c hemicervix of a communicating uterus type 7 and had ipsilateral renal a,a genesis. Compared with the unaffected right hemicervix, only the tumor-invo lved glands of the atretic left hemicervix contained ciliated tuboendometri al cells. Pour and a half years after radical hysterectomy and pelvic radia tion, she showed no evidence of recurrence. Conclusion: In contrast to current opinion, communicating uteri type 7 are associated with ipsilateral renal agenesis. Our histologic findings support the hypothesis that tuboendometrial cells are the cells of origin for cerv ical dear-cell adenocarcinoma (Obstet Gynecol 2000;96:834-6. (C) 2000 by Th e American College of Obstetricians and Gynecologists.).