New peptide labels containing covalently bonded platinum(II) centers as diagnostic biomarkers and biosensors

Authors
Albrecht, M Rodriguez, G Schoenmaker, J van Koten, G
Citation
M. Albrecht et al., New peptide labels containing covalently bonded platinum(II) centers as diagnostic biomarkers and biosensors, ORG LETT, 2(22), 2000, pp. 3461-3464
Citations number
41
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
22
Year of publication
2000
Pages
3461 - 3464
Database
ISI
SICI code
1523-7060(20001102)2:22<3461:NPLCCB>2.0.ZU;2-3
Abstract
[GRAPHICS] Water and acid resistant arylplatinum(ll) complexes have been covalently bo nded to the N-terminus of L-valine, thus providing organometallic biomolecu les with excellent stability properties. Owing to the Pt-195 nucleus (I = 1 /2), these building blocks are potentially versatile biomarkers (e.g., MRI) , Moreover, they display efficient in vitro biosensor characteristics since they detect SO2 gas selectively and fully reversibly by an instantaneous c hange of the spectroscopic properties including a diagnostic Pt-195 NMR sig nal.