The role of mucins in host-parasite interactions. Part I - Protozoan parasites

Parasite-derived mucin-like molecules might be involved in parasite attachm ent to and invasion of host cells. In addition, parasites might secrete muc in-degrading enzymes, enabling the penetration of protective mucus gels tha t overlie the mucosal surfaces of their potential hosts. Furthermore, they might generate binding ligands on the membrane-bound mucins of host cells b y using specific glycosidases. If is possible that host mucins and mucin-li ke molecules prevent the establishment of parasites or facilitate parasite expulsion. They might also serve as a source of metabolic energy and adhesi on ligands for those parasites adapted to exploit them. Sally Hicks and col leagues here review the biochemical properties of mucins and mucin-like mol ecules in relation to interactions (established and putative) between proto zoan parasites and their hosts.