A juvenile case of overlap syndrome of systemic lupus erythematosus and polymyositis, later accompanied by systemic sclerosis with the development ofanti-Ku 70 and anti-Ku antibodies

We describe a 16-year-old girl with An overlap syndrome consisting of syste mic lupus erythematosus (SLE) from the age of 7 and polymyositis (PM) from the age of 10, later accompanied by systemic sclerosis (SSc) from the age o f 15, She was diagnosed as having SLE with exudative malar erythema, photos ensitivity, and discoid rashes with positive antinuclear antibody (ANA) and anti-DMA antibody titers, The diagnosis of PM was also made in accordance with findings of a high titer of muscle enzymes and a muscle biopsy specime n demonstrating marked degeneration of the muscle fibers and perivascular i nfiltration of mononuclear cells. She developed Raynaud's phenomenon and pi tting ulcers on her fingers with positive anti-Scl 70 and anti-Ku antibodie s, leading to a diagnosis of SSc, The patient was treated with prednisolone . To our knowledge this is the youngest case of SLE-PM overlap syndrome lat er accompanied by SSc.