Application of a non-indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids

The need For increased throughput in the quantitation of target compounds i n biological fluids by high performance liquid chromatography/mass spectrom etry continues to drive research in this area. This report describes the ap plication of a prototype dual sprayer electrospray source for the quantitat ive analysis of biological samples. Quantitative performance for 180 compou nds in a microsomal stability assay was found to be adequate when compared with a conventional single sprayer measurement, Issues with use of dual spr ayers in a routine production environment are discussed. Copyright (C) 2000 John Wiley & Sons, Ltd.