Different manifestations of Langerhans cell histiocytosis affecting two members of a family

Two different manifestations of Langerhans cell histiocytosis (histiocytosi s X) a re presented, the first occurring as a solitary rib eosinophil granu loma in an Ii-year-old girl, and the second as an eosinophil granuloma of t he lung of her mother, a 41-year-old heavy smoker, appearing 8 yea rs after the onset of her daughter's disease. Familia I clustering of two different manifestations of histiocytosis X disease is very rare and raises the poss ibility of inherited mutations that promote emergence of clonal Langerhans cells. Copyright (C) 2000 S. Karger AG, Basel.