Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases

Authors
Cutolo, M Wilder, RL
Citation
M. Cutolo et Rl. Wilder, Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases, RHEUM DIS C, 26(4), 2000, pp. 825
Citations number
67
Categorie Soggetti
Rheumatology
Journal title
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
ISSN journal
0889857X → ACNP
Volume
26
Issue
4
Year of publication
2000
Database
ISI
SICI code
0889-857X(200011)26:4<825:DRFAAE>2.0.ZU;2-O
Abstract
Androgens and estrogens modulate susceptibility and progression to autoimmu ne rheumatic disease. At any concentration, androgens seem to be primarily suppressive on cellular and humoral immunity whereas at physiologic concent rations, estrogens seem to enhance humoral immunity and decrease cellular i mmunity.