Quantitative analysis of acetazolamide in solid dosage forms with H-1-NMR spectroscopy

Authors
Senyuva, H Ozden, T Aksahin, I
Citation
H. Senyuva et al., Quantitative analysis of acetazolamide in solid dosage forms with H-1-NMR spectroscopy, SPECT LETT, 33(5), 2000, pp. 661-669
Citations number
3
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
SPECTROSCOPY LETTERS
ISSN journal
00387010 → ACNP
Volume
33
Issue
5
Year of publication
2000
Pages
661 - 669
Database
ISI
SICI code
0038-7010(2000)33:5<661:QAOAIS>2.0.ZU;2-H
Abstract
A rapid and specific proton magnetic resonance spectroscopic method was dev eloped for determining acetazolamide in tablets. Maleic acid was used as th e internal standard and DMSO-d(6) served as the NMR solvent. The concentrat ion of drug per unit dose was calculated from the integration values for th e resonance signals of acetazolamide at 2.14 ppm and maleic acid at 6.20 pp m. The method using commercial products gave comparable results of those ob tained by the method of USP XXIII.