One-step synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones using the CAN-mediated furan ring formation

Authors
Kobayashi, K Tanaka, H Tanaka, K Yoneda, K Morikawa, O Konishi, H
Citation
K. Kobayashi et al., One-step synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones using the CAN-mediated furan ring formation, SYN COMMUN, 30(23), 2000, pp. 4277-4291
Citations number
40
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
23
Year of publication
2000
Pages
4277 - 4291
Database
ISI
SICI code
0039-7911(2000)30:23<4277:OSOFUT>2.0.ZU;2-B
Abstract
The reaction of 1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione with various alkenes or terminal alkynes in the presence of cerium(IV) ammonium nitrate (CAN) afforded the corresponding 5,6-dihydrofuro[2,3-d]pyrimidine-2,4(1H,3H )-diones or furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in moderate to good yie lds.