Yj. Wu et al., Synthesis of N-alpha-pyridylmethyl amino alcohols and application in catalytic asymmetric addition of diethylzinc to aromatic aldehydes, TETRAHEDR-A, 11(17), 2000, pp. 3543-3552
A series of novel chiral ligands 2a-2f were conveniently prepared from beta
-amino alcohols through a two-step reaction and applied to catalyze the en
antioselective addition of diethylzinc to benzaldehyde. Among them, ligand
2c was found to show the best asymmetric induction and catalyze the reactio
n of various aromatic aldehydes to provide (R)-secondary alcohols in up to
98.3% ee. (C) 2000 Elsevier Science Ltd. All rights reserved.