Synthesis and antibacterial activity of metal complexes of ciprofloxacin

Authors
Anacona, JR Toledo, C
Citation
Jr. Anacona et C. Toledo, Synthesis and antibacterial activity of metal complexes of ciprofloxacin, TRANSIT MET, 26(1-2), 2001, pp. 228-231
Citations number
29
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
TRANSITION METAL CHEMISTRY
ISSN journal
03404285 → ACNP
Volume
26
Issue
1-2
Year of publication
2001
Pages
228 - 231
Database
ISI
SICI code
0340-4285(200102)26:1-2<228:SAAAOM>2.0.ZU;2-4
Abstract
The interactions of ciprofloxacin (HCipro) with transition metals have been investigated. Two types of complexes, [M(Cipro)(OAc)(H2O)(2)] . 3H(2)O (M = Mn-II, Co-II, Cu-II or (CdI)-I-I) and [M(Cipro)(OAc)] . 6H(2)O (M = Ni-II or Zn-II), were obtained and characterized by physicochemical and spectros copic methods. The i.r. spectra of the complexes suggest that the ciproflox acin behaves as a monoanionic bidentate ligand. In vitro antibacterial acti vities of the HCipro and the complexes were tested.