Reduced iopromide elimination in hemodialysis with cuprophan membranes

Purpose: To evaluate the influence of different membrane materials on the e fficiency of iopromide elimination. Material and Methods: Twenty stable patients with chronic renal failure aft er coronary angiography were investigated for contrast medium elimination d uring hemodialysis directly after contrast medium application. Results. Clearance during hemodialysis with cuprophan membranes was 102+/-7 mg/ml in contrast to 153+/-4 mg/ml in polysulfone membranes. Elimination h alf-time was 94+/-5 min in cuprophan and 79+/-3 min in polysulfone membrane s, and the elimination rate after 120 min was 59+/-2% and 66+/-1.5%, respec tively. Plasma clearance of iopromide was elevated in polysulfone membranes (188+/-17 ml/min); however, not significantly different to cuprophane memb ranes (153+/-11 ml/min). Accordingly, 24-h urinary iopromide excretion was reduced to 26+/-4 g/24 h vs. 32+/-7 g/24 h. Conclusion. Hemodialysis for iopromide elimination with polysulfone membran es is more effective than with cuprophan membranes.