Prognostic significance of mild mitral regurgitation by color Doppler echocardiography in acute myocardial infarction

Mitral regurgitation (MR) complicating acute myocardial infarction (AMI) is associated with increased mortality. The prognostic significance of only m ild MR detected by echocardiography in patients with AMI is unknown. This s tudy assessed the long-term risk associated with mild MR detected by color Doppler echocardiography within the first 48 hours of admission in 417 cons ecutive patients with AMI. No MR was detected in 271 patients (65%), mild M R was seen in 121 patient; (29%), and moderate or severe MR was noted in 25 patients (6%). One-year mortality rates were 4.8%, 12.4%, and 24%, respect ively (p <0.001). Multivariate analysis revealed that mild MR was independe ntly associated with increased I-year mortality (p <0.05) after adjustment for age, gender, previous myocardial infarction, diabetes mellitus, systemi c hypertension, Killip grade greater than or equal to2 on admission, and le ft ventricular ejection fraction less than or equal to 40%. The hazard rati o for I-year mortality was 2.31 (95% confidence interval 1.03 to 5.20) for mild MR and 2.85 (95% confidence interval 0.95 to 8.51) for moderate or sev ere MR. Thus, mild MR detected by color Doppler echocardiography within the first 2 days of admission in patients with AMI is a significant independen t risk predictor for 1-year all-cause mortality. (C)2000 by Excerpta Medico , Inc.