Effect of heterozygosity for the methionine synthase 2756 A -> G mutation on the risk for recurrent cardiovascular events

Increased dietary intake of folate has been shown to significantly reduce t he risk for fatal myocardial infarction, possibly by lowering homocysteine levels. We therefore investigated the association between recurrent cardiov ascular events and a mutation in methionine synthase (2756 A-->G)-an enzyme directly involved in folate and homocysteine metabolism. This mutation sig nificantly reduced the risk for recurrent cardiovascular events and elevate d red blood cell folate levels.