A new source of drug-induced acute pancreatitis: Codeine

A variety of drugs have been reported to cause acute pancreatitis during th e past 40 years. We report the first series of four cases of acute pancreat itis related to codeine ingestion. Four patients (three female, mean age 50 .2 yr) presented with clinical, biochemical, and radiological evidence of a cute pancreatitis. All four had ingested a therapeutic dose of codeine 1-3 h before the onset of abdominal symptoms. Unintentional rechallenge occurre d in three cases and was followed by recurrence of acute pancreatitis in al l three. All patients made a full recovery. All four patients had had a pre vious cholecystectomy. The likely underlying pathophysiological mechanism i s codeine-induced spasm of the sphincter of Oddi combined with sphincter of Oddi dysfunction related to a previous cholecystectomy. Codeine ingestion leads to acute pancreatitis in some individuals. Previous cholecystectomy s eems to predispose to codeine-induced pancreatitis. (C) 2000 by Am. Cell. o f Gastroenterology.