Js. Felicio et al., Effect of blood glucose on left ventricular mass in patients with hypertension and type 2 diabetes mellitus, AM J HYPERT, 13(11), 2000, pp. 1149-1154
The aim of our prospective study was to evaluate the influence of blood glu
cose (BG) on left ventricular mass and diastolic function in patients with
hypertension and type 2 diabetes mellitus (DM). Fifty-six hypertensive pati
ents with type 2 DM and 26 healthy controls were investigated. They were su
bmitted to echocardiography (ECHO) with Doppler and we calculated the mean
of their fasting BG values, office blood pressure (OBP), cholesterol and fr
actions, and triglycerides during the previous 4 years. The diabetic patien
ts were then followed-up for 1 year with OBP, fasting BG, and lipids measur
ed every 2 months. After this period, the patients were again submitted to
ECHO and in 22 patients (group I [GI]), reductions greater than 10% in left
ventricular mass index (LVMI) were observed (122 +/- 35 nu 89 +/- 23 g/m(2
), P < .01), whereas increases greater than 10% (group II [GII], n = 17) (9
4 +/- 18 <nu> 115 +/- 27 g/m(2), P < .01) or no changes (group III [GIII],
n = 17) (98 +/- 16 <nu> 99 +/- 18 g/m2, NS) in LVMI were detected in the re
maining patients. The OBP values did not change during the follow-up. In GI
the reduction of LVMI was associated with a BG fall from 178 +/- 36 to 147
+/- 30 mg/dL (P < .01) and a correlation was observed between BG and LVMI
percent variations (<Delta>) (r = 0.48, P < .01). No important changes in l
eft ventricular diastolic function were observed during the follow-up. We c
oncluded that the improvement in glycemic control may contribute to LVH reg
ression in hypertensive patients with type 2 DM. Am J Hypertens 2000; 13:11
49-1154 (C) 2000 American Journal of Hypertension, Ltd.