Down's syndrome is associated with increased 8,12-iso-iPF(2 alpha)-VI levels: Evidence for enhanced lipid peroxidation in vivo

postmortem and in vitro studies have shown that oxidative stress plays a ro le in the pathogenesis of many of the clinical features of Down's syndrome. The isoprostane 8,12-iso-iPF(2 alpha)-VI is a specific marker of lipid per oxidation. We found elevated levels of this isoprostane in urine samples of subjects with Down's syndrome compared with those of matched controls, whi ch correlated with the duration of the disease. These results suggest that increased in vivo lipid peroxidation is a prominent component early in the course of Down's syndrome.