Citation
D. Pratico et al., Increased 8,12-iso-iPF(2 alpha)-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity, ANN NEUROL, 48(5), 2000, pp. 809-812
Citations number
19
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134
→ ACNP
Volume
48
Issue
5
Year of publication
2000
Pages
809 - 812
Database
ISI
SICI code
0364-5134(200011)48:5<809:I8AIAD>2.0.ZU;2-S
Abstract
The isoprostane 8,12-iso-iPF(2 alpha)-VI is a sensitive and specific marker
of in vivo lipid peroxidation. We found elevated levels in the urine, bloo
d and cerebrospinal fluid of patients with Alzheimer's disease (AD) that co
rrelated with measures of cognitive and functional impairment, established
biomarkers of AD pathology (cerebrospinal fluid tau and amyloid) and the nu
mber of apolipoprotein E epsilon4 alleles. These results suggest that 8,12-
iso-iPF(2 alpha)-VI is a useful biomarker of oxidative damage in AD.