Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia

Authors
Lloveras, E Sole, F Espinet, L Besses, C Asensio, A Abella, E Woessner, S Florensa, L
Citation
E. Lloveras et al., Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia, CANC GENET, 121(2), 2000, pp. 163-166
Citations number
26
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
121
Issue
2
Year of publication
2000
Pages
163 - 166
Database
ISI
SICI code
0165-4608(200009)121:2<163:CAFISH>2.0.ZU;2-J
Abstract
We present a cytogenetic and fluorescence in situ hybridization (FISH) stud y, using centromeric probes for chromosomes 3, 7, 11, and 18, TP53 gene (17 p13), and RE-I locus (13q14) DNA probes, in four cases of plasma cell leuke mia (PCL). Among the four cases, three presented monosomy of the RB-1 locus and one monoallelic deletion of the TP53 gene. The present report shows th e usefulness of the FISH technique to detect abnormalities not previously o bserved by conventional cytogenetics. (C) 2000 Elsevier Science Inc. All ri ghts reserved.