Deletion of 3 '-CBFB gene in association with an inversion (16)(p13q22) and a loss of the Y chromosome in a 2-year-old child with acute myelogenous leukemia-M4

Authors
Batanian, JR Huang, YF Fallon, R
Citation
Jr. Batanian et al., Deletion of 3 '-CBFB gene in association with an inversion (16)(p13q22) and a loss of the Y chromosome in a 2-year-old child with acute myelogenous leukemia-M4, CANC GENET, 121(2), 2000, pp. 216-219
Citations number
10
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
121
Issue
2
Year of publication
2000
Pages
216 - 219
Database
ISI
SICI code
0165-4608(200009)121:2<216:DO3'GI>2.0.ZU;2-P
Abstract
Inversion 16(p13q22) is most commonly associated with acute myelomonocytic leukemia with abnormal eosinophils (M4). III association with this inversio n, a proximal deletion at the 16p13 primary arm breakpoint occurs in 20% of cases. We report on a first case of inversion IG with a distal deletion at the primary arm breakpoint 16q22, detected by using the fluorescent-labele d dual-color probe CBFB. (C) 2000 Elsevier Science Inc. All rights reserved .