Unusual RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide mimic (POM)

Authors
Hickman, DT King, PM Cooper, MA Slater, JM Micklefield, J
Citation
Dt. Hickman et al., Unusual RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide mimic (POM), CHEM COMMUN, (22), 2000, pp. 2251-2252
Citations number
16
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
22
Year of publication
2000
Pages
2251 - 2252
Database
ISI
SICI code
1359-7345(2000):22<2251:URADBP>2.0.ZU;2-X
Abstract
A pentameric thymidyl pyrrolidine-amide oligonucleotide mimic (POM) was syn thesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.