The central cleavage of beta,beta-carotene - A supramolecular mimic of enzymatic catalysis

Authors
Woggon, WD
Citation
Wd. Woggon, The central cleavage of beta,beta-carotene - A supramolecular mimic of enzymatic catalysis, CHIMIA, 54(10), 2000, pp. 564-568
Citations number
19
Categorie Soggetti
Chemistry
Journal title
CHIMIA
ISSN journal
00094293 → ACNP
Volume
54
Issue
10
Year of publication
2000
Pages
564 - 568
Database
ISI
SICI code
0009-4293(2000)54:10<564:TCCOB->2.0.ZU;2-3
Abstract
The enzyme beta,beta -carotene 15,15'-dioxygenase which cleaves beta,beta - carotene to retinal (provitamin A) has been identified for the first time i n chicken intestinal mucosa and subsequently sequenced and expressed in two different cell lines. To mimic this unusual metabolism a supramolecular re ceptor has been synthesized which binds beta,beta -carotene with K-a = 8.3 x 10(6) M-1 and it was shown that the corresponding oxo-ruthenium complex c atalyzes the selective cleavage of carotenoids.