Synthesis and relaxivity of polycarboxylic hydrazone rare earth complexes - Relaxivity of alpha-oxo-pentanedioic acid benzoyl hydrazone Gd-complexes

Authors
Yang, ZY Li, FS Yang, L Yang, RD
Citation
Zy. Yang et al., Synthesis and relaxivity of polycarboxylic hydrazone rare earth complexes - Relaxivity of alpha-oxo-pentanedioic acid benzoyl hydrazone Gd-complexes, CHIN SCI B, 45(20), 2000, pp. 1844-1850
Citations number
10
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
45
Issue
20
Year of publication
2000
Pages
1844 - 1850
Database
ISI
SICI code
1001-6538(200010)45:20<1844:SAROPH>2.0.ZU;2-X
Abstract
Synthesis of ligand, alpha -oxo-pentanedioic acid benzoyl hydrazone (H2LPB) , and its six rare earth (La, Pr, Nd, Sm, Gd and Er) complexes are reported . The composition and the properties of the complexes were characterized by element analysis, thermal analysis, UV, IR and H-1 NMR spectra. Besides, r elaxivity (R-1) of Gd-complex has been determined by INVREC.Au program, usi ng inversion recovery pulse sequences, R-1=8.05 mmol.L-1.s(-1). The acute t oxicity of Gd-complex in animal has also been tested, and the median lethal dose (LD50) is equal to (468.2+/-30) mg/kg.