I. Schulze-neick et al., Severe airflow limitation after the unifocalization procedure - Clinical and morphological correlates, CIRCULATION, 102(19), 2000, pp. 142-147
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-While unifocalization techniques have improved the treatment opt
ions in patients with pulmonary atresia, ventricular septal defect (PA-VSD)
, and major aortopulmonary collaterals (MAPCAs), severe airflow limitation
contributes to significant early postoperative morbidity and mortality. Alt
hough this has been attributed to bronchospasm, characteristically it is re
fractory to bronchodilators, suggesting that other mechanisms may play a ro
le.
Methods and Results-The clinical course and preoperative angiograms of pati
ents who underwent unifocalization were reviewed. Patients who developed ai
rflow limitation early after surgery underwent Fiberoptic bronchoscopy. In
addition, the anatomy of the MAPCAs was examined in 14 heart-lung blocks fr
om patients with PA-VSD, Twenty-two procedures were performed in 16 childre
n. Three developed marked airflow limitation early after surgery, necessita
ting prolonged high-pressure ventilation. Bronchoscopy demonstrated tracheo
bronchial epithelial necrosis in 2 and signs of tracheobronchial ischemia i
n the third. Two were successfully extubated after 15 and 16 days, but the
third died after 57 days of ventilatory support. Review of the preoperative
angiograms demonstrated an extensive peribronchial arterial supply arising
from a MAPCA in 1 of the patients who developed severe airway necrosis aft
er unifocalization. This was also obvious in a second patient, but the MAPC
A was not included in the unifocalization. In 7 autopsy specimens, MAPCAs c
ontributed to a peribronchial or peritracheal vascular network. Dissection
of the distribution of these branches in 2 specimens revealed extensive int
rapulmonary peribronchial anastomoses,
Conclusions-Airflow limitation early after unifocalization is related to ai
rway ischemia resulting from interruption of the tracheobronchial blood sup
ply during mobilization of MAPCAs.