The role of different subsets of T regulatory cells in controlling autoimmunity

Authors
Roncarolo, MG Levings, MK
Citation
Mg. Roncarolo et Mk. Levings, The role of different subsets of T regulatory cells in controlling autoimmunity, CURR OP IM, 12(6), 2000, pp. 676-683
Citations number
80
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
12
Issue
6
Year of publication
2000
Pages
676 - 683
Database
ISI
SICI code
0952-7915(200012)12:6<676:TRODSO>2.0.ZU;2-X
Abstract
T regulatory cells - in addition to clonal deletion and energy - are essent ial for the downregulation of T cell responses to both foreign and self ant igens, and for the prevention of autoimmunity. Recent progress has been mad e in characterising the different subsets of T regulatory cells, the factor s that drive their differentiation, and their mode of action. The resolutio n of these mechanisms will make it possible to use T regulatory cells thera peutically in human autoimmune diseases.