Spiny keratoderma of the palms and soles - report of two cases

We report two patients with spiny keratoderma of the palms and soles charac terized by multiple tiny keratotic plugs on the palms and soles. This disea se was reported to be possibly associated with internal malignancies. We fo und a tumor from the esophagus to cardia in one patient, Another had no tum or but the lesion occurred soon after a severe bronchial asthma attack. Cau sal relation between spiny keratoderma of the palms and soles and bronchial asthma is obscure. Since this disease has been under-diagnosed and under-r eported, it is important for dermatologists to keep spiny keratoderma of th e palms and soles in mind in daily clinical examinations.