Photodynamic therapy in dermatology

Application of non-ionising radiation with or without photosensitisers is r ather common in dermatology. Though the method itself was described in anci ent times, its routine use in medicine based on scientific research started in the second half of the 20th century. Light can be used in three differe nt patterns: phototherapy (UV-A or UV-B light), photochemotherapy (combinat ion of psoralens with UV-A light) and photodynamic therapy (combination of photosensitisers with UV- and/or visible light). The following article deal s with the photodynamic therapy or PDT. Using PDT implies the understanding of light dosimetry and calculation of light dose using different light sou rces and photosensitisers. The number of PDT sensitisers under investigatio n is rapidly increasing. The PDT itself, being a relatively new modality, q uickly spreads its list of applications covering new indications in differe nt areas of medicine. Though the main part of this list is made up of derma tological conditions, the use of PDT in other disciplines is also discussed to make dermatologists familiar with different aspects of the issue. PDT, like any treatment modality, has its benefits and adverse effects. The futu re of PDT is closely related to teamwork ill physical, biochemical and clin ical research which could provide better understanding of underlying mechan isms and help to create protocols for higher therapeutic efficacy.