Arterial thrombosis associated with anticardiolipin and anti-beta 2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma: a report of two cases
I. Genvresse et al., Arterial thrombosis associated with anticardiolipin and anti-beta 2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma: a report of two cases, EUR J HAEMA, 65(5), 2000, pp. 344-347
Autoimmune phenomena in lymphoid malignancies are often observed. However,
clinical manifestations such as a secondary antiphospholipid syndrome in th
e presence of antiphospholipid antibodies are rarely reported. Furthermore,
in the few cases of lymphomas so far reported with thrombosis associated w
ith elevated antiphospholipid antibodies, the anti-beta2-glycoprotein-I ant
ibodies have not been studied. We report on two cases of arterial thrombosi
s occuring in patients with B-cell lymphoma who presented with positive ant
icardiolipin and anti-beta2-glycoprotein-I antibodies. Our observation sugg
ests that patients with non-Hodgkin's lymphoma and both anticardiolipin and
anti-beta2-glycoprotein-I antibodies may be, similar to lupus patients, at
considerable risk towards thrombosis, especially towards arterial thrombos
is.