Synthesis of a highly hydrophobic dimeric Lewis X containing glycolipid: Amodel for the study of homotypic carbohydrate-carbohydrate interaction

Authors
Bregant, S Zhang, YM Mallet, JM Brodzki, A Sinay, P
Citation
S. Bregant et al., Synthesis of a highly hydrophobic dimeric Lewis X containing glycolipid: Amodel for the study of homotypic carbohydrate-carbohydrate interaction, GLYCOCON J, 16(12), 1999, pp. 757-765
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
GLYCOCONJUGATE JOURNAL
ISSN journal
02820080 → ACNP
Volume
16
Issue
12
Year of publication
1999
Pages
757 - 765
Database
ISI
SICI code
0282-0080(199912)16:12<757:SOAHHD>2.0.ZU;2-2
Abstract
This paper describes the synthesis of an octasaccharidic glycolipid 1 based on a stereo- and regioselective glycosylation between a Lewis X trisacchar idic donor and a pentasaccharidic acceptor. A highly hydrophobic lipid moie ty of a new type was selected, making the compound 1 a good candidate for t he study of the interaction of Lewis X functionalised vesicles.