A simple stereoselective synthesis of aplysinopsin analogs

Authors
Selic, L Jakse, R Lampic, K Golic, L Golic-Grdadolnik, S Stanovnik, B
Citation
L. Selic et al., A simple stereoselective synthesis of aplysinopsin analogs, HELV CHIM A, 83(10), 2000, pp. 2802-2811
Citations number
29
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
83
Issue
10
Year of publication
2000
Pages
2802 - 2811
Database
ISI
SICI code
0018-019X(2000)83:10<2802:ASSSOA>2.0.ZU;2-4
Abstract
Simple and stereoselective syntheses of aplysinopsins and their analogs fro m either methyl 2-[(2,2 disubstituted ethenyl)amino]-3-(dimethylamino)prop- 2-enoates or 5-[(dimethylamino)methylidene]imidazolidine-2,4-diones 20 are described. The structures of products are established by H-1 and C-13-NMR. and NOESY spectroscopy, and X-ray crystal-structure analysis.