New synthesis of KT5823 indolocarbazole aglycone

Authors
Burtin, GE Madge, DJ Selwood, DL
Citation
Ge. Burtin et al., New synthesis of KT5823 indolocarbazole aglycone, HETEROCYCLE, 53(10), 2000, pp. 2119
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
10
Year of publication
2000
Database
ISI
SICI code
0385-5414(20001001)53:10<2119:NSOKIA>2.0.ZU;2-I
Abstract
The indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycone of the selective protein kinase G inhibitor KT5823 has been synthesised in four steps and 36% overal l yield from 2,3-dichloro-N-methylmaleimide by utilising an efficient new t wo step reduction sequence for the key imide to amide transformation.