Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitaniuim: Synthesis of 5,12-dimethylindolizino[2,1-g]isoquinoline (ellipticine analogue)

Citation
Y. Miki et al., Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitaniuim: Synthesis of 5,12-dimethylindolizino[2,1-g]isoquinoline (ellipticine analogue), HETEROCYCLE, 53(10), 2000, pp. 2123
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
10
Year of publication
2000
Database
ISI
SICI code
0385-5414(20001001)53:10<2123:RO3AW(>2.0.ZU;2-P
Abstract
Reaction of indolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)t riisopropoxytitanium gave 2-(3-bromoisonicotinoyl)-3-ethoxycarbonyl-indoliz ine-1-carboxylic acid as the sole product. The indolizine-l-carboxylic acid could be converted to 5,12-dimethylindolizine[2,1-g] isoquinoline in six s teps.