Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitaniuim: Synthesis of 5,12-dimethylindolizino[2,1-g]isoquinoline (ellipticine analogue)
Y. Miki et al., Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitaniuim: Synthesis of 5,12-dimethylindolizino[2,1-g]isoquinoline (ellipticine analogue), HETEROCYCLE, 53(10), 2000, pp. 2123
Reaction of indolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)t
riisopropoxytitanium gave 2-(3-bromoisonicotinoyl)-3-ethoxycarbonyl-indoliz
ine-1-carboxylic acid as the sole product. The indolizine-l-carboxylic acid
could be converted to 5,12-dimethylindolizine[2,1-g] isoquinoline in six s
teps.