A double-blind, randomized trial of the efficacy and safety of short-course, once-daily levofloxacin versus ofloxacin twice daily in uncomplicated urinary tract infections

Uncomplicated UTIs are a frequently occurring infection, especially in youn g women. In this comparative study, patients were assigned randomly to 3 da ys of levofloxacin 250 mg once daily or ofloxacin 200 mg twice daily, Micro biologic and clinical outcomes were assessed after therapy (5-9 days) and a fter the study (4-6 weeks). At the posttherapy (test-of-cure) visit, 96.3% of pathogens were eradicated in the levofloxacin group, compared with 93.6% for ofloxacin, Symptoms were resolved or improved to the point where no fu rther antibiotics were required in 98.1% of patients receiving levofloxacin and 97% of those receiving ofloxacin, The authors conclude that the short course regimens of levofloxacin and ofloxacin were equally effective and we ll-tolerated for the treatment of uncomplicated urinary tract infections in women.