Spectral and magnetic properties and bio-activity of copper(II) clofibriates Part I. Crystal and molecular structure of trans-Cu(clofibriate)(2)(nicotinamide)(2)

New copper(II) clofibriate (clof) Cu(clof)(2) and its compounds of composit ion Cu(clof)(2)L-2 (where L = nicotinamide (na) or ronicol (ron)) and Cu(cl of)(2)-caffeine are reported. The characterizations were based on elemental analysis, electronic and EPR spectra, and magnetic susceptibility measurem ents over the temperature range 4.5-300 K. The crystal and molecular struct ure of Cu(clof)(2)(na)(2) has been determined. The copper(II) atom is bonde d in a trans square-planar arrangement by two N atoms of two nicotinamide m olecules and one carboxylate oxygen atom from each of two clofibriate anion s. The remaining two carboxylate oxygen atoms of the anions at the axial po sitions completed a tetragonal-bipyramidal geometry. On the basis of spectr al and magnetic properties structures of the compounds were proposed. The a ntimicrobial effects have been tested on various strains of bacteria, yeast s and filamentous fungi. (C) 2000 Elsevier Science S.A. All rights reserved .